Roberta is a bored suburban housewife who is fascinated with a woman, Susan, she only knows about by reading messages to and from her in the personals section of the newspaper. This fascination reaches a peak when an ad with the headline "Desperately Seeking Susan" proposes a rendezvous. Roberta goes too, and in a series of events involving amnesia and mistaken identity, steps into Susan's life.
Wealthy Sunny von Bülow lies brain-dead, husband Claus guilty of attempted murder; but he says he's innocent and hires Alan Dershowitz for his appeal.